Study on in vitro microdialysis recovery of hydroxycamptothecine

• DOI: 10.4268/cjcmm20121030
• Publication Date: 2012-06-21T15:45:56Z
• Authors: XIE Yi
• Keywords: Microdialysis; Recovery rate

To establish the mothod to dectect microdialysis recovery of HCPT and investigate influencing factors, thus supply experimental basis for in-vivo HCPT.The in vitro was detected by concentration difference method (increment decrement method). The influence flow rates, medium temperature on stability were studied.The increment same as method. independent concentrations medium. hydroxycamptothecine had good increased rose.Microdialysis sampling can be used pharmacokinetic study HCPT. Retrodialysis determination vivo recovery.