Efficacy of Artemisinin-Based Combination Treatments of Uncomplicated Falciparum Malaria in Under-Five-Year-Old Nigerian Children Ten Years Following Adoption as First-Line Antimalarials

• DOI: 10.4269/ajtmh.18-0115
• Publication Date: 2018-06-26T07:01:01Z
• Authors: Joy C. Ebenebe; Godwin Ntadom; Jose Ambe; Robinson Wammanda; Nma Jiya; Finomo Finomo; George Emechebe; Olugbenga Mokuolu; Kazeem Akano; Chimere Agomo; Onikepe A. Folarin; Stephen Oguche; Francis Useh; Wellington Oyibo; Temitope Aderoyeje; Mohammed Abdulkadir; Nnenna M. Ezeigwe; Christian Happi; Akintunde Sowunmi; _ _
• Keywords: Artemether/lumefantrine; Dihydroartemisinin; Piperaquine; Artemether; Artesunate

The efficacies of 3-day regimens artemether-lumefantrine (AL), artesunate-amodiaquine (AA), and dihydroartemisinin-piperaquine (DHP) were evaluated in 910 children < 5 years old with uncomplicated malaria from six geographical areas Nigeria. Parasite positivity 1 day Kaplan-Meier estimated risk persistent parasitemia 3 days after therapy initiation both significantly higher, geometric mean parasite reduction ratio treatment (PRRD1) was lower AL-treated than AA- DHP-treated children. No history fever, temperature > 38°C, enrollment 75,000 μL