Risk Factors of Leishmania Infection among HIV-Infected Patients in Trang Province, Southern Thailand: A Study on Three Prevalent Species

• DOI: 10.4269/ajtmh.20-0332
• Publication Date: 2020-07-21T07:01:08Z
• Authors: Sakarn Charoensak...; Lertwut Bualert; Jipada Manomat; Mathirut Mungthin; Saovanee Leelayoova; Peerapan Tan-ariya; Suradej Siripatta...; Tawee Naaglor; Phunlerd Piyaraj
• Keywords: Opportunistic infection

There are two main species of Leishmania reported in Thailand, that is, siamensis and martiniquensis. Moreover, leishmaniasis cases caused by donovani complex were also reported. is still a lack information concerning risk factors infection Thailand. This study aimed to identify the these three among HIV-infected patients. A cross-sectional was conducted HIV clinic at Trang Hospital, Nested PCR sequencing performed detect DNA blood saliva samples species. standardized questionnaire used interview individuals. total 526 patients recruited this study. Sixty-three (12.0%) positive for L. siamensis, 24 (4.6%) martiniquensis, 23 (4.4%) complex. Risk included using intravenous drug (adjusted odds ratio [AOR] 2.01, 95% CI: 1.01-4.02). martiniquensis female gender (AOR 4.23, 1.52-11.75), recreational 3.43, 1.00-11.74), having comorbidities 4.94, 2.00-12.21). opportunistic 4.22, 1.00-17.79), CD4 count 200-500 cells/mm3 3.64, 1.14-6.86), not insect repellent 3.04, 1.08-8.58). identified The data could be useful disease prevention control. Further studies on trends preventive measures recommended.