Occurrence of Anti-Rickettsia spp. Antibodies in Hospitalized Patients with Undifferentiated Febrile Illness in the Southern Region of Kazakhstan

• DOI: 10.4269/ajtmh.20-0388
• Publication Date: 2021-04-26T13:31:28Z
• Authors: Nurkeldi Turebekov; Karlygash Abdiyeva; Ravilya Yegemberd...; Andrey Kuznetsov; Andrey Dmitrovskiy; Lyazzat Yeraliyeva; Zhanna Shapiyeva; Dinara Batyrbayeva; Nur Tukhanova; Anna Shin; Lyazzat Musralina; Michael Hoelscher; Guenter Froeschl; Gerhard Dobler; Klaus Freimueller; Edith Wagner; Stefan Frey; Sandra Essbauer
• Keywords: Rickettsia typhi; Boutonneuse fever

Undifferentiated febrile illness still represents a demanding medical problem all over the world, but primarily in low- and middle-income countries. Scientific clinical investigations related to undifferentiated rickettsial diseases Kazakhstan are lacking. This study reflects investigation of antibodies against spotted fever group (SFG) typhus (TG) rickettsiae patients with southern region (Almaty Kyzylorda oblasts). Paired serum samples were gathered from 13 hospitals these two oblasts explored for presence IgM IgG using ELISA. Patient's questionnaires statistically analyzed. In total, 802 inpatients Almaty (N = 9) 4) included this research. Based on ELISA results, 250 out (31.2%) both had SFG rickettsiae. Results 11 (1.4%) indicated acute infection tick-borne rickettsiosis. Regarding TG (R. typhi), past was detected 248 (30.9%) 22 (2.7%) selected oblasts. The data that rickettsioses present Kazakhstan. Kazakh physicians should be aware emerging investigated because occurrence is not suspected during day-to-day practice. identification pathogens implementation modern laboratory methods diagnostics need throughout