Bothrops moojeni snake venom-induced renal glomeruli changes in rat.

• DOI: 10.4269/ajtmh.2002.67.217
• Publication Date: 2017-05-10T16:44:48Z
• Authors: Patrícia Aline B...; José Antonio Roc...; Maria Alice Cruz-...
• Keywords: Bothrops

The venom of Bothrops moojeni has potent proteolytic and phospholipase A2 activities. In previous work, we showed that intravenous injection this in rats decreased creatinine clearance caused tubular dysfunction histopathological changes with no alterations blood pressure. current study used scanning transmission electron microscopy to assess the ultrastructural by B. (0.4 mg/kg i.v.) rat renal glomeruli correlated these severity proteinuria 5 hours, 16 48 hours after injection. included mesangiolysis, glomerular microaneurysms, basement membrane (GBM) abnormalities. addition, there was a reduction number width podocyte pedicels, which filtration slits. Electron-dense amorphous material, may be proteinaceous origin, found pedicels. abnormalities level proteinuria. These morphophysiological were attributed biochemical physiological disturbances components GBM mesangial matrix as well cytoskeleton-associated proteins podocytic processes, could account for breakdown optimal barrier functioning. results, together absence appreciable fibrin deposits, support hypothesis direct activity on kidneys. Proteolytic then contribute onset acute failure, would explain clinical manifestations injury bites other species.