PLASMODIUM VIVAX: TRANSMISSION-BLOCKING IMMUNITY IN A MALARIA-ENDEMIC AREA OF COLOMBIA

• DOI: 10.4269/ajtmh.2005.73.5_suppl.0730038
• Publication Date: 2017-08-22T06:05:08Z
• Authors: MYRIAM ARÉVALO-H...; YEZID SOLARTE; FELIPE ZAMORA; FABIÁN MENDEZ; MARIA FERNANDA YA...; LEONARDO ROCHA; CAROLE LONG; LOUIS H. MILLER; SÓCRATES HERRERA
• Keywords: Serial dilution; Blocking antibody

Plasmodium vivax transmission-blocking activity was assessed in sera from acutely infected patients a malaria-endemic area Colombia. We measured reduction the number of oocysts that developed midguts Anopheles albimanus mosquitoes artificially fed with blood these patients. Of 88 mosquito batches infections when parasites were mixed normal AB human serum, one-third (36.4%) showed full (≥ 90% inhibition) autologous sera, 29.6% partial (50–89%), 17.0% did not block transmission (0–50%), and 17% enhance transmission. Transmission-blocking correlated antibody titer by an immunofluorescent test decreased serial dilution sera. This disappeared at 1:4 most tested. Afro-Colombian individuals lower than other ethnic groups febrile produced stronger inhibition those without fever.