Intramural Component of Venous, Lymphatic, and Perineural Invasion in Colon Cancer: A Threat or an Illusion?

• DOI: 10.4274/balkanmedj.galenos.2022.2022-6-94
• Publication Date: 2022-10-31T06:53:17Z
• Authors: Leyla Özer; Elif Şenocak Taşçı; Arda Ulaş Mutlu; Betül Piyade; Nur Ramoğlu; Miraç Ajredini; Damla Gürleyik; Recep Çeçen; Sena Nur Dinçer; Turan Musevitoğlu; Süha Göksel; Ümit İnce; Cavit Kerem Kayhan; Sibel Erdamar; İbrahim Yıldız; Erman Aytaç
• Keywords: Perineural invasion; Lymphovascular invasion; Vascular invasion

Extramural venous invasion is an independent predictor of poor outcome in colorectal cancer, whereas the significance intramural component and lymphatic perineural unclear.To evaluate prognostic impact components for venous, lymphatic, invasions relation these patterns with clinicopathological features patients colon cancer.A retrospective cross-sectional study.The analysis included 626 cancer stages II III. All were divided into four categories (no invasion, only, extramural or both invasions) vascular invasion. The primary outcomes 5-year disease-free overall survival.Right-sided (for 24.7% vs. 33.9%, p = 0.007; 34.5% 41.5%, 0.034) dMMR tumors 13.5% 33.5, < 0.001; 25% 41.4%, 0.004) exhibited less Compared no presence did not exert any effect on survival Multivariate analyses revealed that was independently associated (hazard ratios: 2.39, hazard 2.46, 0.001), 2.456, 2.13, 0.02) 2.99, 2.68, respectively.Our data strongly advocates importance reporting since alone may be considered as a high-risk factor systemic recurrence.