Frequency of Celiac Disease and Spontaneous Normalization Rate of Celiac Serology in Children and Adolescent Patients with Type 1 Diabetes

• DOI: 10.4274/jcrpe.galenos.2020.2020.0108
• Publication Date: 2020-08-21T13:03:10Z
• Authors: Edip Unal; Meliha Demiral; Birsen Baysal; Mehmet Ağın; Elif Gökçe Deveci...; Hüseyin Demirbilek; Mehmet Nuri Özbek
• Keywords: Adult; Male; Adolescent; type 1 diabetes; Remission, Spontaneous; Comorbidity; Pediatrics; RJ1-570; Diseases of the endocrine glands. Clinical endocrinology; Young Adult; 03 medical and health sciences; 0302 clinical medicine; children; Humans; Child; Autoantibodies; Retrospective Studies; spontaneous normalization; RC648-665; 3. Good health; Celiac Disease; Diabetes Mellitus, Type 1; Child, Preschool; Original Article; Female; celiac disease

The prevalence of celiac disease (CD) varies between 1% and 10% in patients with type 1 diabetes mellitus (T1DM). This study aimed to determine the frequency spontaneous recovery serology biopsy-proven CD (BPCD) T1DM.The data 668 available tests from a total 779 who were followed for last 10 years diagnosis T1DM retrospectively evaluated.Positive was detected 103 out (15.4%) patients. There normalization 24 (23.3%), fluctuation 11 (10.7%) permanently positive 68 (66%). In 46 53 (86.8%) biopsy, confirmed by biopsy (BPCD). BPCD 6.9%, 76.1% at time T1DM. weight, height body mass index-standard deviation score lower compared group without CD. An anti-tissue transglutaminase-IgA (anti-TTG-IgA) level 11.8 times upper limit normal most sensitive (93%) specific (90%) cut-off (area under curve: 0.95; 95% confidence interval: 0.912-1; p<0.001).In our cohort, 15.4%, while rate 6.9%. majority (97.8%) cases diagnosed within first five 23.3% cases, anti-TTG-IgA spontaneously resolved gluten-free diet (GFD). Therefore, serological follow-up instead immediate duodenal or GFD therapy, particularly asymptomatic mild anti-TTG IgA level, is warranted.