Frequency and Clinical Impact of Microsatellite Instability in Colorectal Dysplasia Subgroups

• DOI: 10.4274/tjcd.galenos.2023.2023-1-10
• Publication Date: 2023-06-20T06:21:43Z
• Authors: Seçil Ak Aksoy; Tuncay Yılmazlar; Melis Erçelik; Çağla Tekin; Nesrin Uğraş; Ömer Yerci; Ersin Öztürk; Selim Gürel; Özgen Işık
• Keywords: Microsatellite Instability

Aim: The risk of colorectal cancer development associated with low-grade dysplasia (LGD) and high-grade (HGD) colon polyps at baseline polypectomy remains unclear.In this study, we investigated the role microsatellite instability (MSI) in formation prognosis dysplasia.Method: In 40 diagnosed as HGD, LGD were evaluated according to revised Vienna criteria (2015) a result polypectomy.MSI analysis was performed by fragment using five different primers.Results: Three eight HGD turned into during follow-up period.The rate MSI sporadic determined 36.3.A significant correlation found between status polyp recurrence within five-year period after polypectomy. Conclusion:In our it that HGDs can recur, but may be effective preventing cases MSI.