Analysis of Altered Baseline Brain Activity in Drug-Naive Adult Patients with Social Anxiety Disorder Using Resting-State Functional MRI

• DOI: 10.4306/pi.2015.12.3.372
• Publication Date: 2015-07-13T10:47:17Z
• Authors: Changjian Qiu; Yuan Feng; Yajing Meng; Wei Liao; Xiaoqi Huang; Su Lui; Chunyan Zhu; Huafu Chen; Qiyong Gong; Wei Zhang
• Keywords: Superior frontal gyrus; Middle frontal gyrus; Middle temporal gyrus; Limbic lobe; Fusiform gyrus; Medial frontal gyrus; Parahippocampal gyrus; Lingual gyrus; Inferior temporal gyrus; Inferior frontal gyrus; Drug-naïve; Superior temporal gyrus; Gyrus

We hypothesize that the amplitude of low-frequency fluctuations (ALFF) is involved in altered regional baseline brain function social anxiety disorder (SAD). The aim study was to analyze activity drug-naive adult patients with SAD.We investigated spontaneous and activities by obtaining resting-state functional magnetic resonance imaging data 20 drug-naïve SAD 19 healthy controls. Voxels were used ALFF values using one- two-sample t-tests. A post-hoc correlation clinical symptoms also performed.Our findings show decreased bilateral insula, left medial superior frontal gyrus, precuneus, middle temporal right pole, fusiform gyrus group. exhibited significantly increased inferior occipital orbital parahippocampal gyrus. Moreover, Liebowitz Social Anxiety Scale results for positively correlated mean Z but showed a negative gyrus.These suggest regions abnormal are underlying pathophysiology patients.