Microwave assisted facile one pot synthesis of novel 5-carboxamido substituted analogues of 1,4-benzodiazepin-2-one of medicinal interest

• DOI: 10.4314/bcse.v27i2.16
• Publication Date: 2013-05-21T04:30:12Z
• Authors: P. Sharma; N. Kaur; P. Sharma; R. Sirohi; D. Kishore
• Keywords: Morpholine; Piperidine; Piperazine; Carboxylate; Primary (astronomy); One-pot synthesis; Derivative (finance)

A novel synthetic approach developed by the use of a microwave (MW) assisted one pot protocol to synthesis methyl-1,4-benzodiazepin-2-one-5-carboxylate (2) derivatives for which N-chloroacetylisatin was employed with an elegant success afford formation 5-methyl carboxylate 1,4-benzodiazepines from its reaction methanolic hexamine. We have utilized MW technique in present work conducting ester derivative several selected primary and secondary amines 3, 4, 5, 6, 7, 8 had previous history being biologically active literature, generate corresponding carboxamide (9-14). KEY WORDS: Morpholine, Piperidine, Piperazine, Pyridine, Pyrimidine Bull. Chem. Soc. Ethiop. 2013, 27(2), 301-307.DOI: http://dx.doi.org/10.4314/bcse.v27i2.16