Prevalence and Significance of Sickle Cell Trait in Nigerian Patients with Essential Hypertension

• DOI: 10.4314/tjhc.v18i2.69607
• Publication Date: 2011-11-30T04:09:53Z
• Authors: SG Ahmed; MS Mijinyawa; AH Kwaru; M Sanusi; A Abba
• Keywords: Sickle cell trait

Dr Sagir G. Ahmed, Department of Haematology Aminu Kano Teaching Hospital PMB 3452, State, Nigeria. [phone] [e-mail] Abstract lifestyle and nutritional culture the Africans are Global epidemiology shows that hypertension becoming increasingly westernized over time is severer, commoner occurs at relatively younger might be partly responsible for rising incidence nonage in black comparison to whites. communicable diseases, including hypertension, Since sickle cell trait (SCT) was associated with Africa. This consistent finding higher hyperviscosity, we hypothesize SCT a possible prevalence urban populations 1 risk factor blacks it Nigeria . Moreover, adult high severity appears as previous studies blacks. Hence, studied reported rates about 12% 1992, 20% 1, 2, 3 haematological parameters 1999 up 36% more recent study 2008 hypertensive patients evaluated impact had shown on response anti-hypertensive therapy seen 4, 5, Hospital, age than white Europeans 6 The WBC 9 platelet counts 5.8 x10 /L 225 did not Individuals have significantly differ from corresponding values red cells Hb AS genotype contain 40% 7 6.2 235 among HbS 60% HbA abundance prevents normotensive controls (p>0.05), but sickling under physiological conditions haematocrit 0.37L/L frequency 20-25% West Africa lower value 0.44L/L Nigeria, has reached (p 0.05). Hypertensive normal AA mean systolic diastolic pressures 158 95 Haemorheological revealed systemic mm Hg were arterial blood pressure generally influenced by 145 86 vascular peripheral resistance, which turn affected 12, 13 (p<0.05). These viscosity We therefore results suggest essential poor patients. Hence race. If our hypothesis need closer monitoring during therapy. correct, predicted that: