HYPERURICEMIA AND ITS ASSOCIATION WITH HYPERTENSION: RISK FACTORS AND MANAGEMENT

• DOI: 10.47144/phj.v55i2.2251
• Publication Date: 2022-07-06T03:39:29Z
• Authors: Kanwal Ashiq; Sana Ashiq; Naureen Shehzadi
• Keywords: Association (psychology)

Hyperuricemia is a medical condition that arises due to the increased concentration of uric acid in body. Worldwide, surge number hyperuricemia cases has been seen over last ten years. develops when persistently crossed its normal threshold value (6 mg/dL). Uric metabolic product purine catabolism. During metabolism purine, hypoxanthine formed which later on converted xanthine and by action oxidase enzyme. A continual increase levels major biomarker developing gouty arthritis. Clinically, arthritis characterized inflammation pain joints accumulation urate crystals around affected area.1 Recently, hyperuricemia-induced renal cardiovascular diseases have gained more consideration. not only associated with gout but also linked other comorbidities, including diabetes type II, heart diseases, hypertension. cohort study demonstrated threefold rise incidence diabetes, hypertension, kidney patients suffering from hyperuricemia. Epidemiological reports revealed factors leading hyperlipidemia, obesity are commonly existed side-by-side may considerably threat organ damage.2,3 According estimation, 1.13 billion people globe Also, World Health Organization indicated 13% deaths happen worldwide hypertension they set goal decreasing frequency 25% baseline year 2010 2025. The concept association between blood pressure perhaps quite old identified years ago. Multiple studies established an independent pressure. However, impact this direct causality yet be determined.4,5 In 1870s, first time Mahomed et al had presented hypothesis association. Later, Cannon al. conducted study, their research results verified 47% were hypertensive elevated acids. Previous findings suggested participates pathological process disorder. there still no credible information available reveals will control adults. So far, it known use acid-lowering agents improve patients. Xanthine inhibitors effective serum helpful impeding production reactive oxygen species (ROS). potential benefit controlling appraised required regard. metabolic, renal, monitoring essential (blood pressure: >140/90 mmHg) who family history prehypertension 120–139/80–89 comorbidities like diabetes. Uricosuric antihypertensive drugs (for example losartan) diet management can proved useful. diuretics should avoided these At present, we haven’t enough evidence based well-made clinical trials advocate for treatment above all mention potentially harmful effects. Febuxostat become better alternative because effective, tolerated, specific than allopurinol. regard, long-term interventional required.6 Conversely, as together, drug having effects might reduce concentration. Traditional medicine systems option several ailments, particularly countries. Currently, scientists showed interest natural remedies safe, economical. Medicinal plants enriched sources various active metabolites such flavonoids, tannins, saponins, alkaloids many therapeutic activities different studies. future, experimental needed validate usefulness explore possible pharmacological toxicological effects.7,8 References Ashiq K, Bajwa MA, Tanveer S, Qayyum M, Khokhar R, comprehensive review gout: epidemiological trends, pathophysiology, presentation, diagnosis treatment. J Pak Med Assoc. 2021;71(4):1234-8. Gaubert Bardin T, Cohen-Solal A, Diévart F, Fauvel J-P, Guieu coronary artery disease, disease: practice. Int Mol Sci. 2020;21(11):4066. Zhang Y, Yu X, Wei Chen C, Association hypertriglyceridemia incident hyperuricemia: 8-year prospective study. Trans Med. 2020;18(1):1-8. Stewart DJ, Langlois V, Noone D. hypertension: links risks. Integr Blood Press Control. 2019;12:43. S. COVID-19 pandemic Heart J. 2021;54(3):275-6. De Becker B, Borghi Burnier Van Borne P. focused practical recommendations. Hypertension. 2019;37(5):878-83. Hussain Islam Shehzadi N, Ali E, Pakistan inhibition activity treat systematic review. Turkish Botany. 2021;45(SI-2):723-38. Tămaş Vostinaru O, Soran L, Lung I, Opris Toiu Antihyperuricemic, Anti-Inflammatory Antihypertensive Effect Dry Extract Solidago virgaurea L.(Asteraceae). Sci Pharm. 2021;89(2):27.