Application of Newly Developed and Validated Analytical Method for Interaction Study of Selected Cardiac Drug Under Clinical Trials for Combination Therapy

• DOI: 10.47583/ijpsrr.2023.v79i01.020
• Publication Date: 2023-04-15T11:48:42Z
• Authors: Blessy Thomas; Dr. Prasanth S.S; Panchami G.S; Reeba K.R
• Keywords: Drug trial; Pharmacotherapy

This research work aims to develop a new, rapid, accurate, and precise FTIR method for the simultaneous estimation of Propranolol Hydrochloride Amiodarone Hydrochloride.are used treatment cardiovascular diseases application developed determine interaction by closely observing their interactive peaks.Acc. WHO, Cardiovascular are group disorders heart blood vessels.As per statistics, about 1.7 million deaths reported yearly due CVD.The was validated according ICH guidelines.Amiodarone shows better solubility in methanol is increased addition DMSO (Dimethyl sulfoxide).Sample preparation not required since ATR were used.For drugs, Beer's-Lambert's law obeyed concentration range 0.5-5.0mg 3.8-10.3mgrespectively.96.6% 98.59% percentage recovery drugs respectively FTIR.Correlation coefficient found be 0.996 0.999 Amiodarone.FTIR.This can useful no analytical combination.The applicability determined carrying out studies concluded positive result physical between both.