The association between TNF-receptors (TNFR1 and TNFR2) and mortality as well as kidney function decline in patients with chronic kidney disease

• DOI: 10.48101/ujms.v129.10726
• Publication Date: 2024-11-27T15:15:45Z
• Authors: Per Wändell; Tobias Feldreich; Anders Larsson; Philip A. Kalra; Johan Ärnlöv; Toralph Ruge; Axel C. Carlsson
• Keywords: Quartile

Background: Higher circulating levels of tumor necrosis factor (TNF) alpha receptors 1 (TNFR1) and 2 (TNFR2) are associated with increased long-term mortality impaired kidney function. Aim: To study associations between TNFR1 TNFR2 all-cause as well estimated glomerular filtration rate (eGFR) decline. Population methods: Patients chronic disease (CKD) stages 3–5 in the Salford Kidney Study were included. Associations one standard deviation increase plasma by Cox regression models hazard ratios (HRs) 95% confidence intervals adjusted for age, sex, eGFR based on creatinine cystatin C, urine-protein, C-reactive protin, cardiovascular comorbidity, smoking habits, diabetes. Differences decline relation to both linear logistic models, coefficients odds (ORs). Results: Univariate showed significant (n = 985) 988) 7424 person-years at risk, but fully continuous variables only HR 1.17 (1.03–1.34), a borderline value 1.15 (1.00–1.31). For rapid decliners, that is, highest TNFR-receptor quartile versus quartiles 1–3, was 1.60% per month (interval 0.78–10.99). ORs 1.29 (0.92–1.81) 1.33 (0.90–1.98). Conclusions: mortality, not, although showing value. Neither nor predicted portray interesting aspects patients CKD, clinical utility seems limited.