Physical model of serum supplemented medium flow in organ-on-a-chip systems

• DOI: 10.48550/arxiv.2409.13650
• Publication Date: 2024-09-20
• Authors: Viesturs Šints; Jānis Cı̄murs; Mihails Birjukovs; Ivars Driķis; Karīna Goluba; Kaspars Jēkabsons; Vadims Parfejevs; Una Riekstiņa; Gatis Mozoļevskis; Roberts Rimša; Guntars Kitenbergs
• Keywords: Fluid Dynamics (physics.flu-dyn); Soft Condensed Matter (cond-mat.soft); FOS: Physical sciences; Physics - Fluid Dynamics; Condensed Matter - Soft Condensed Matter

Creating a physiologically relevant shear stress in organ-on-a-chip (OOC) devices requires careful tailoring of microfluidic flow parameters. It is currently fairly common to use simple approximation assuming constant viscosity, even for serum-based media. Here, we show that popular nutrient solution (Dulbecco's Modified Eagle Medium supplemented with Fetal Bovine Serum) more complex treatment (i.e., non-Newtonian fluid), observed values significantly greater than reported literature. We measure the rheology solutions and combine it 3-dimensional field measurement derive at channel surface. verify experiments numerical simulations, finding good agreement deriving properties. Finally, provide expressions approximation, suitable development OOC various geometries.