Facilitated Protein-DNA Binding: Theory and Monte Carlo Simulation

• DOI: 10.5012/bkcs.2012.33.3.971
• Publication Date: 2012-04-26T07:18:01Z
• Authors: Ki-Hyun Park; Tae-Jun Kim; Hyo-Joon Kim
• Keywords: 01 natural sciences; 0104 chemical sciences

The facilitated diffusion effect on protein-DNA binding is studied. A rigorous theoretical approach is presented to deal with the coupling between one-dimensional and three-dimensional diffusive motions. For a simplified model, the present approach can provide numerically exact results, which are confirmed by the lattice-based Monte Carlo simulations.