Preventive Effects of Multi-Lamellar Emulsion on Low Potency Topical Steroid Induced Local Adverse Effect

• DOI: 10.5021/ad.2013.25.1.5
• Publication Date: 2013-02-25T09:11:01Z
• Authors: Geun Dong Sul; Hyun Jung Park; Jong Hwan Bae; Keum Duck Hong; Byeong Deog Park; Jaesun Chun; Se Kyoo Jeong; Seung Hun Lee; Sung Ku Ahn; Hyun Jung Kim
• Keywords: Lotion; Transepidermal water loss; Erythema; Topical steroid

Background: Topical steroid treatment induces diverse local Wand systemic adverse effects.Several approaches have been tried to reduce the steroid-induced effects.Simultaneous application of physiological lipid mixture is also suggested.Objective: Novel vehicles for topical glucocorticoids formulation were evaluated efficacy reducing side-effects and drug delivery properties desonide, a low potency steroid.Methods: Transcutaneous permeation skin residual amount desonide measured using Franz diffusion cells.The in vivo anti-inflammatory activity was murine model.Results: steroids containing either cream or lotion form, prepared multi-lamellar emulsion (MLE), conventional formulations employed comparison.MLE did not affect phobol ester-induced inflammation model, compared with formulations.While penetrated amounts similar all tested at 24 hours after application, increased lag time observed MLE formulations.Interestingly, epidermis significantly higher type formulation.Steroid-induced effects, including permeability barrier function impairment, partially prevented by formulation.Conclusion: as vehicle showed better epidermal retention.MLE side such impairment.