The Antimicrobial Activity of (-)-Epigallocatehin-3-Gallate and Green Tea Extracts againstPseudomonas aeruginosaandEscherichia coliIsolated from Skin Wounds

• DOI: 10.5021/ad.2014.26.5.564
• Publication Date: 2014-10-08T10:21:32Z
• Authors: Jiehyun Jeon; Joo Ha Kim; Chang Kyu Lee; Chil Hwan Oh; Hae Jun Song
• Keywords: Green tea extract

Background: Skin infections with Gram-negative bacteria are sometimes challenging to treat, because these show multidrug resistance against commonly used antibiotics and patients bacterial infection overall have deteriorated in conditions many cases.Studies shown that epigallocatechin gallate (EGCG) green tea extracts (GTE) inhibit the growth of several Gram-positive species.Objective: The purpose this study was investigate minimum inhibitory concentrations (MICs) EGCG GTE Pseudomonas aeruginosa Escherichia coli, assess use chemicals as an alternative or adjunct topical antimicrobial agent P. E. coli resistance.Methods: MICs EGCG, GTE, other tested were measured compared determine antibacterial efficacy differences pattern resistance.Results: strains showed resistance.EGCG inhibited at a MIC level 200∼400 μg/ml.The 1 : 16 dilution for aeruginosa.EGCG activity 400 μg/ml.In case between 1：8 1：4 coli.Conclusion: potential agents resistant traditional antibiotic therapy.