Association between Multiplate-measured aspirin resistance and vitamin D deficiency in stable coronary artery disease

• DOI: 10.5114/amsad.2021.112242
• Publication Date: 2022-05-26T08:35:45Z
• Authors: Semih Surmen; Pelin Karaca Ozer; Samim Emet; Elif Ayduk Govdeli; Ali Elitok
• Keywords: 03 medical and health sciences; 0302 clinical medicine; Clinical Research; 3. Good health

Insufficient inhibition of platelets in patients with atherosclerosis despite antiplatelet therapy leads to important clinical consequences. The present study evaluated the role vitamin D (VD) deficiency aspirin resistance (AR) stable coronary artery disease (CAD) treated aspirin.This included 70 CAD who had been using 100 mg for at least seven days. Serum 25-hydroxyvitamin [25-(OH)D] concentration was measured and 25-(OH)D level < 20 ng/dl were defined as VD deficient group. A Multiplate Platelet Function Analyzer (Multiplate) device used evaluate AR. Patients aspirin-sensitive (AS) when their AUC ≤ 30 U, resistant > U.AUC U 15 (21%) these considered mean 18.7 ±12.2 ng/ml all patients. Forty-five (64%) deficient. rate AR higher group than sufficient (29% vs. 8%, p = 0.041). (30.2 ±29.1 15.3 ±13.1 U; 0.018). In ROC analysis 19.25 predicted 86.7% sensitivity, 61.8% specificity (AUC 0.696, 95% CI: 0.551-0.840, 0.021).In current study, an association found between CAD. supplementation may reduce platelet aggregation overcome