Chromosome abnormalities identified in 457 spontaneous abortions and their histopathological findings

• DOI: 10.5146/tjpath.2015.01303
• Publication Date: 2015-04-06T04:57:46Z
• Authors: Sezin Yakut; Havva Serap Toru; Zafer Cetin; Deniz Ozel; Mehmet Simsek; Inanc Mendilcioglu; Guven Luleci
• Keywords: Trisomy; Products of conception

Objective: About 15% of clinically recognized pregnancies result in spontaneous abortion the first trimester and vast majority these are chromosome abnormalities.Studies chromosomal constitutions abortions have revealed that at least 50% an abnormal karyotype.In this study we aimed to report single centre experience anomalies detected abortions. Material Method:We present rare numerical structural cytogenetic abnormalities materials histopathological findings rest material specimens our population.Results: Among 457 cases, 382 were successfully karyotyped while cell culture 75 cases failed.Cytogenetic 127 (33.24%).Autosomal trisomies predominant with a frequency 48.8%.Structural infrequent conception materials.The mean age mothers was highest trisomy group, difference being significantly important (ANOVA p< 0.001).The most frequent Turner syndrome, triploidy 16 followed by chromosomes 22 21 tetraploidy.Double rare.Trisomies more advanced maternal age. Conclusion:Detection is very clarify causes loss pregnancy.Detection their carrier parents can provide proper genetic counseling families.These families be directed towards pre-implantation diagnosis prevent further complications.