Inversed albumin-to-globulin ratio and underlying liver disease severity as a prognostic factor for survival in hepatocellular carcinoma patients undergoing transarterial chemoembolization

• DOI: 10.5152/dir.2022.211166
• Publication Date: 2023-01-12T14:20:13Z
• Authors: Jinlong Li; Zhi Li; ; Shirui Hao; ; Jitao Wang; ; Wei Chen; ; Shoufang Dai; ; Zhenguo Hou; ; Borun Chen; ; Yewei Zhang; ; Dengxiang Liu
• Keywords: Nomogram; Univariate analysis; Milan criteria

Previous studies have shown that an inversed albumin-to-globulin ratio (IAGR) is a predictor of the prognosis many cancers. However, prognostic value IAGR for patients with hepatocellular carcinoma (HCC) who undergo transarterial chemoembolization (TACE) still unclear. This study aims to evaluate predictive those patients.This retrospectively analyzed 396 HCC received TACE. Using cut-off 1.0 ratio, were divided into normal (NAGR) (≥1) and (<1) group. Univariate multivariate analyses time-dependent receiver operating characteristic performed identify risk factors overall survival (OS) cancer-specific (CSS). Survival nomograms constructed based on multivariable analysis results further evaluated using consistency index (C-index) calibration curve.A total included in final NAGR group (n = 298, 75.3%) 98, 24.7%) The median OS CSS significantly worse than (OS: 8 vs. 26 months, CSS: 10 41 both P < 0.001). Multivariate demonstrated was independent factor predicting [hazard (HR), 2.024; 95% confidence interval (CI): 1.460-2.806] (HR: 2.439; CI: 1.651-3.601). nomogram-based model-related C-indexes prediction 0.715 (95% 0.697-0.733) 0.750 0.729-0.771), nomogram showed good consistency.The along underlying liver disease severity useful predictors among undergoing TACE might be high-risk patients.