Relation between serum quantitative HBsAg, ALT and HBV DNA levels in HBeAg negative chronic HBV infection

• DOI: 10.5152/tjg.2014.5711
• Publication Date: 2015-04-22T14:35:33Z
• Authors: Ozgur Gunal; Sener Barut; Ilker Etikan; Fazilet Duygu; Umut Tuncel; Mustafa Sunbul
• Keywords: HBeAg; Hepatitis B

In this study, we aimed to investigate whether quantitative HBsAg and alanine aminotransferase (ALT) levels correlated with Hepatitis B Virus (HBV) DNA in patients HBeAg negative chronic HBV infection.Ninetynine were divided into two groups; inactive carriers (IC) active (AC) DNA>2000 IU/mL. These groups compared terms of ALT levels. Quantitative measurements performed Elecsys II Quant assay (Roche Diagnostic).Mean age was 43.11±14.79 years. values IC AC 2.47±1.35 log10 IU/mL, 3.59±0.97 IU/mL (p=0.0001), 25.94±13.06 55.54±82.38 (p=0.015), respectively the difference significant. When ROC analysis determine most appropriate value define carrier patients, area under curve for 0.738 (95% CI:0.637-0.840). A cut-off 2147 revealed sensitivity 76% specificity 70% diagnosing IC. Also, a significant correlation also found between (log) (r: 0.503, p=0.0001).It has been concluded that could be used differentiate patients.