A fast sample shuttle to couple high and low magnetic fields. Applications to high-resolution relaxometry

• DOI: 10.5194/mr-2024-25
• Publication Date: 2025-01-24T13:08:54Z
• Authors: Jorge A. Villanue...; Andreas Tilch; Ana Paula Aguilar...; Guillaume Bouvignies; Frank Engelke; Fabien Ferrage; Agnes Glémot; Ulric B. le Paige; Giulia Licciardi; Claudio Luchinat; Giacomo Parigi; Philippe Pelupessy; Enrico Ravera; Alessandro Ruda; Lucas Siemons; Olof Stenström; Jean-Max Tyburn
• Keywords: Sample (material)

Abstract. Combining high-field high-resolution NMR with an evolution of spin systems at low magnetic field offers many opportunities for the investigation molecular motions, hyperpolarization and exploration field-dependent dynamics. Fast reproducible transfer between high fields is required to minimize polarization losses due longitudinal relaxation. Here, we introduce a new design sample shuttle that achieves remarkably speeds, vmax ~ 27 m.s-1. This hybrid pneumatic/mechanical apparatus compatible conventional probes center. We show applications water relaxometry in solutions paramagnetic ions, proton small molecule shuttling solution 42 kDa protein. Importantly, this fast system narrow, diameter d = 6 mm container based on standard 5 outer glass tube, which should allow near access manipulation field.