Correlation Between Serum Ferritin and Gonadotrophins and Sex Hormones in Patients with Transfusion Dependent â-Thalassemia

• DOI: 10.52206/jsmc.2021.11.2.88-95
• Publication Date: 2021-06-10T05:37:50Z
• Authors: Humaira Fayyaz Khan; Ahmed Orakzai; Shaista Alam; Asfandyar Roghani; Mohammed Naveed; Ubaid Ullah
• Keywords: Beta thalassemia

Background: Patients with transfusion dependent beta thalassemia major develop a number of complications whichhypogonadism is the most common. In addition, raised serum ferritin level has been associated hypogonadism.Objective: To determine correlation between ferritin, gonadotrophins and sex hormones in patients transfusiondependent â-thalassemia syndrome patients.Material methods: This cross sectional study was designed conducted at Institute Basic Medical Sciences (IBMS),Khyber University (KMU) Peshawar Fatimid Foundation, blood bank hematological services Peshawar. Betathalassemia enrolled were 97. Blood samples collected from subjects analyzed atIBMS KMU using chemiluminescence immune assay for determination gonadal such as FSH, LH,Estradiol Testosterone.Results: The mean±SD age 18.93±3.6 years range 15-32 years. There 55 (56.7%) males 42(43.3%) females. Overall hypogonadism diagnosed 39 (40.21%) patients. Although we did not find any association betweenserum function our study, having had higher (p = 0.02). Astatistically significant negative found LH, FSH testosterone males(p <0.05).Conclusion: effect iron overload on more pronounced ascompared to female thalassemic patients.Keywords: Beta Thalassemia syndrome, Chelation, Ferritin, Hypogonadism, Gonads, Sex Hormones