Histological and immunohistochemical profile of lymphocytic duodenitis and features of local immune reactions

• DOI: 10.52340/gs.2023.05.04.23
• Publication Date: 2023-12-12T13:08:17Z
• Authors: Tamar Nikolaishvili; Tsitsino Parulava; Inga Mamuchishvili; Nino Kantaria; George Burkadze
• Keywords: Intraepithelial lymphocyte; Common Variable Immunodeficiency; Duodenitis; Lymphocytic infiltration; Lymphocytosis

Lymphocytic enteritis is characterised by abnormal infiltration of intraepithelial lymphocytes in the intestinal mucosa. It was described as duodenal lymphocytosis or lymphocytic duodenitis. Nowadays, represents a common feature several gluten-mediated and non-gluten-related diseases. The most frequent causes are gluten-related disorders (celiac disease, non-celiac gluten sensitivity), Helicobacter pylori infection drug-related damages. Less frequently, may be secondary to autoimmune conditions, immunoglobulin deficiencies, bacterial viral infections irritable bowel syndrome. Therefore, differential diagnosis challenging.