Quantitative gait analysis in children with osteogenesis imperfecta: relationship between gait deviations and clinical features

• DOI: 10.52628/88.2.9117
• Publication Date: 2022-08-24T11:03:17Z
• Authors: Solange De Wouters; Christine Detremb...; Anne Durnez; Philippe Mahaudens; Brice Henry; Jean Schrooyen; Pierre-Louis Docq...
• Keywords: Diphosphonates; Infant, Newborn; Bisphosphonates; Osteogenesis Imperfecta; 3. Good health; 03 medical and health sciences; 0302 clinical medicine; Humans; Osteogenesis imperfecta; Instrumented gait analysis; Prospective Studies; Child; Gait Analysis; Gait biomechanical deviations; Gait; Gait biomechanical deviations.

Osteogenesis imperfecta is a rare congenital disease of connective tissue characterized by recurrent fractures and progressive skeletal deformities which may impact on gait. The aims this prospective study were to identify gait deviations in children with osteogenesis compared age-matched controls establish relationships clinical features. We evaluated 22 patients different types using three-dimensional analysis. incidence location frac- tures, fracture at birth, age first fracture, use intramedullary rodding number surgical in- terventions the lower extremities, bone mineral density, hypermobility injections bisphosphonates recorded for each patient. Step length was group control group. Kinematics showed that sagittal pelvic transversal hip range motion higher group, whereas knee during swing phase reduced. Regarding kinetics, flexion moment negative power peak significantly decreased Mechanical energetic parameters considered as normal. principal component analysis revealed density increased who had received more jections these also less deficit kinematic parameters. Main modifications observed spatiotemporal, kinetic data. More studies are necessary allow stratification severity disease, help improve its challenging multidisciplinary treatment ob- jectively assess outcomes.