Green Synthesis, Multitargeted Molecular Docking and ADMET Studies of Chalcones Based Scaffold as Anti-Breast Cancer Agents

• DOI: 10.52711/0974-360x.2023.00364
• Publication Date: 2023-07-10T10:43:23Z
• Authors: Jainey P. James; Pramatha Pramatha; Mariyam Jouhara; Zakiya Fathima C; Rupal Ria D’Souza
• Keywords: Chalcone; MTT assay; Anticancer drug

Green synthesis of chalcones is a new alternative to traditional methods, which eco-friendly and require no solvents. The exert their anticancer action by the different mechanisms acting through various targets. study aimed synthesise green chemistry approach using grinding technique check molecular interactions pharmacokinetic profile in silico studies. Their anti-breast cancer was analysed MTT assay against human breast cells. ADMET physicochemical properties emphasised drug-likeness bioavailability synthesised chalcones. All twelve interacted well with three targets (3ERT, 4OAR 4WKQ). Among them, top were PR2 PR3, excellently interacting targets, are following vitro PR3 have obtained good cytotoxic Based on these results, it concluded that can be utilised as leads agents, verified vivo studies future