Evaluation of Some Maternal and Neonatal-Associated Risk Factors in Early On-Set Neonatal Thrombocytopenia in Delta State, Nigeria

• DOI: 10.5281/zenodo.4641282
• Publication Date: 2021-03-28
• Authors: Collins Ohwonigho...; Emmanuel Asuquo Etim; Mathias Abiodun E...; Humphrey Benedo O...; Zaccheaus Awortu ...
• Keywords: 03 medical and health sciences; 0302 clinical medicine; Neonatal, thrombocytopenia, maternal, neonatal risk factors; 3. Good health

ABSTRACT Background: The growing prevalence of neonatal thrombocytopenia at birth in recent times is a source of concern. Hence, the assessment of maternal and neonatal risk factors associated with early on-set neonatal thrombocytopenia to forestall any complications that may lead to lifelong residual defects or even death among new-borns in this locality. Methods: From a total of 374 newborns at birth, 35 (9.4%) newborns developed thrombocytopenia and served as cases while, 339 (90.6%) were non-thrombocytopenic newborns and served as controls for this study between April 2016 and November 2016. Platelet count was determined on cord blood immediately after delivery using Sysmex KX-21N auto-haematology analyzer. Platelet count from the analyzer correlated with the estimated platelet count from the peripheral blood film evaluation. Results: Incidence of twin delivery (33.3%) was higher among the risk factors associated with neonatal thrombocytopenia. Twin gestation was significantly associated with neonatal thrombocytopenia (P = 0.0062). Conclusion: New-borns from mothers with multiple pregnancies should be thoroughly evaluated for any possible complications of thrombocytopenia at birth to reduce perinatal morbidity and mortality.