Reversal Effects of Sugammadex in Diabetic Patients Having Neuromuscular Block with Rocuronium

• DOI: 10.5336/medsci.2014-41225
• Publication Date: 2015-03-09T09:15:08Z
• Authors: Özlem ERSOY; Yavuz DEMİRARAN; Gülbin SEZEN; İlknur Suidiye ŞEKER; İbrahim KARAGÖZ; Abdulkadir İSKENDER; Şengül CANGÜR
• Keywords: Sugammadex; Neuromuscular monitoring; Neuromuscular transmission

Objective: In our study we aimed to compare the time of antagonism and effect sugammadex which is used for rocuronium on diabetic nondiabetic patients. Sugammadex a new generation antagonist neuromuscular blockade effects by encapsulating molecules in junction through acting like synthetic receptor rocuronium. Material Methods: Included patients were divided into two groups: (n=21) non-diabetic (n=20). After loss eyelid reflex automatically identification supramaximal stimulating current monitoring system, 0.6 mg/kg IV was administered. Train-of-four (TOF) stimulation with applied recording second TOF value patient intubated. performed recorded every 20 seconds. Intraoperatively return T2, 0.15 T2i as intubation whereas T2d clinical time. At end operation 2 When ratio reached 0.9, extubated interval recorded. Results: There no differences between groups (p=0.696). The 2549.6±913.2 [2360 (1144-4718)] seconds diabetics 2208.9±475.0 [2252 (1310-3015)] non-diabetics (p=0.145). Extubation (time from administration reaching 0.9) 434.6±857.1 [205 (67-4120)] 250.4±108.4 [247 (106-462)] (p= 0.948). Recovery extubation an Aldrete's score 0,9) 295,19±239,21 [228 (20-945)] 228,20±115,22 [238.5 (54-446)] (p=0.611). statistical significant difference time, recovery Conclusion: Contrary expected delay times conventional reversal agents resulting complications has not occurred sugammadex. conclusion, seems be good alternative because its role reversing blocking well alleviating problems period.