Impact of vaccination on COVID-19 severity during the second wave in Brunei Darussalam, 2021

• DOI: 10.5365/wpsar.2024.15.1.992
• Publication Date: 2024-06-17T03:46:01Z
• Authors: Chee Fui Chong; Muhammad Syafiq A...; ; Pui Lin Chong; ; Rosmonaliza Asli; ; Babu Ivan Mani; ; Natalie Raimiza M...; ; Justin Wong; ; Noor Afizan Rahman; ; Jackson Tan; ; Vui Heng Chong
• Keywords: Univariate analysis

Objective: Coronavirus disease (COVID-19) vaccinations have been shown to prevent infection with efficacies ranging from 50% 95%. This study assesses the impact of vaccination on clinical severity COVID-19 during second wave in Brunei Darussalam 2021, which was due Delta variant. Methods: Patients included this were randomly selected those who admitted National Isolation Centre between 7 August and 6 October 2021. Cases categorized as asymptomatic, mild (symptomatic without pneumonia), moderate (pneumonia), severe (needing supplemental oxygen therapy) or critical mechanical ventilation) but for statistical analysis purposes dichotomized into asymptomatic/mild moderate/severe/critical cases. Univariate multivariable analyses conducted identify risk factors associated disease. Propensity score-matched also performed evaluate severity. Results: The cohort 788 cases (mean age: 42.1 + 14.6 years; 400 males) comprised 471 (59.8%) 317 (40.2%) Multivariable logistic regression showed older age group (>45 years), diabetes mellitus, overweight/obesity status be increased In propensity analysis, relative developing fully vaccinated (two doses) partially (one dose) 0.33 (95% confidence interval [CI]: 0.16–0.69) 0.62 CI: 0.46–0.82), respectively, compared a control non-vaccinated corresponding reduction (RRR) values 66.5% 38.4%, respectively. Vaccination protective against subgroup overweight/obese patients (RRR: 37.2%, P = 0.007). Discussion: Among contracted COVID-19, age, having diabetes, being unvaccinated significant Vaccination, even partial,