Niacin: Does It affect 8-hydroxy-2-deoxyguanosine levels of the patients having low HDL cholesterol levels?

• DOI: 10.5455/medscience.2013.02.8060
• Publication Date: 2013-03-05T11:50:54Z
• Authors: Ece Harman; Serkan Akcay; Yanki Buke; Hakan Er
• Keywords: Affect; Niacin; Deoxyguanosine; 8-Hydroxy-2'-deoxyguanosine

We aimed to determine whether niacin improve plasma HDL-cholesterol levels by decreasing 8-Hydroxydeoxyguanosine (8-OHdG) as a biomarker of oxidative DNA damage or not. Patients (n=32) with low (40 mg/dl) were included in the study. Lipoprotein profiles (total cholesterol, HDL-C, and total triglycerides) measured all patients. LDL-C was calculated described Friedewald et al. Before after 16 week therapy serum 8-OHdG measured. There significant difference between pre post treatment HDL-C levels. concluded that may raise The improvement have protective effect on endothelial dysfunction. By reducing level 8-OHdG, decrease damage. Thus, be consider an alternative statins fibrates patients whom fail sufficiently correct