Exposure to low-dose bisphenol A induces spleen damage in a murine model: Potentially through oxidative stress?

• DOI: 10.5455/ovj.2022.v12.i1.4
• Publication Date: 2022-01-24T17:22:26Z
• Authors: Taher Shaibi; Hanan Balog; Rabia Alghazeer; Mohamed Othman; Ahmeda Benjama; Mohamed Elhensheri; Bashir Lwaleed; Mohamed Griw
• Keywords: White pulp; Red pulp; Corn oil; Immunotoxicology; Malondialdehyde

During early life, exposure to environmental toxicants, including endocrine disruptor bisphenol A (BPA), can be detrimental the immune system. To our knowledge, a few researches have looked at effects of developing BPA exposures on spleen.The murine model was developed investigate underlying molecular mechanisms and mode actions spleen subsequent prolonged early-life BPA.Immature (3-week-old) male female Swiss Albino mice were intraperitoneally injected with 50 μg/kg in corn oil or alone for 6 weeks. Mouse spleens harvested examined histologically 10 weeks old (adulthood).We observed neurobehavioral impairments significant increase peripheral monocyte lymphocyte counts (males females). Moreover, several abnormalities both adulthood. BPA-treated mice's histopathological results revealed toxicity form significantly active germinal centers white pulp apoptotic cells. There also notable invasion red by eosinophils lymphocytes that higher than normal. Agarose gel electrophoresis provided further evidence internucleosomal DNA fragmentation apoptosis splenic tissues compared controls. In addition, there increased levels lipid peroxidation malondialdehyde end-product, marker oxidative damage, controls.Our study provides stress injury induced could contribute range tissue damages during