Application of Ultrasound-Assisted Extraction on the Stem Bark of Rhinachantus Nasutus (L.) Kurz, Total Phenolic, and Its Potential as Antioxidant and Inhibitor of Alpha-Glucosidase Enzyme Activity

• DOI: 10.5530/pj.2021.13.164
• Publication Date: 2021-09-09T10:02:37Z
• Authors: Candra Irawan; Berna Elya; Muhammad Hanafi; Fadlina Chany Sap...
• Keywords: IC50; Alpha-glucosidase

Aims: This study aims to obtain a stem bark extract of Rhinachantus nasutus (L.) Kurz through the application ultrasound-assisted extraction (UAE) and reveal: total phenolic content in extract; The extract's potential as an antioxidant with copper-reducing strength parameters, its antidiabetic by inhibiting alpha-glucosidase activity. Results: crude ethanol R. obtained from UAE process was 7.4896 g yield 4.99%. high content, namely 677.3343±0.0007 mg GAE / sample, activity test using CUPRAC method gave IC50 value 18.43±0.20 L. In addition, has ability inhibit enzyme 10.95±0.28 Conclusion: source antioxidants antidiabetic.