Elevated Small Dense Low-Density Lipoprotein Cholesterol as a Predictor for Future Cardiovascular Events in Patients with Stable Coronary Artery Disease

• DOI: 10.5551/jat.23465
• Publication Date: 2014-04-07T23:52:43Z
• Authors: Tenjin Nishikura; Shinji Koba; Yuya Yokota; Tsutomu Hirano; Fumiyoshi Tsunoda; Makoto Shoji; Yuji Hamazaki; Hiroshi Suzuki; Yasuki Itoh; Takashi Katagiri; Youichi Kobayashi
• Keywords: Glycated hemoglobin; Stroke

Aim: The aim of the present study was to investigate how small dense low-density lipoprotein cholesterol (sdLDL-C) compared with LDL-C affect long-term prognosis in patients stable coronary artery disease (CAD). Methods: sdLDL-C measured by heparin magnesium precipitation and LDL particle size non-denatured gradient-gel electrophoresis were 190 consecutive CAD who underwent arteriography between 2003 2004 did or not develop cardiovascular events during a seven-year follow-up period. Cardiovascular death caused diseases(CVDs), onset acute syndrome, need for peripheral arterial revascularization, hospitalization heart failure, surgical procedure any CVDs, and/or stroke. Results: First-time observed 72 patients. Those experienced older had higher prevalence rates hypertension diabetes; significantly Gensini atherosclerotic scores; levels sdLDL-C, sdLDL-C/LDL-C, LDL-C/high-density (HDL-C) ratios; greater glycated hemoglobin(Hb)A1c brain natriuretic peptide (BNP) levels. They also smaller sizes, HDL-C, apolipoprotein A-1, estimated glomerular filtration rate (GFR) without events. Conversely, LDL-C, non-HDL-C, B, remnantlike cholesterol, high-sensitivity C-reactive protein (hs-CRP) similar two groups. A Kaplan-Meyer event-free survival curve demonstrated that sdLDL-C≥35 mg/dL (median level) poorer those lower levels, while ≥100 non-significantly rate. Conclusion: These results confirm is very promising biomarker predict future secondary prevention CAD.