Association of Serum Levels of Cholesterol Absorption and Synthesis Markers with the Presence of Cardiovascular Disease: The CACHE Study CVD Analysis

• DOI: 10.5551/jat.64119
• Publication Date: 2023-04-24T22:16:24Z
• Authors: Shunsuke Katsuki; Tetsuya Matoba; Yusuke Akiyama; Hiroshi Yoshida; Kazuhiko Kotani; Hisako Fujii; Mariko Harada-Shiba; Yutaka Ishibashi; Tatsuro Ishida; Yasushi Ishigaki; Daijiro Kabata; Yasuki Kihara; Satoshi Kurisu; Daisaku Masuda; Kota Matsuki; Takeshi Matsumura; Kenta Mori; Tomoko Nakagami; Masamitsu Nakazato; Satsuki Taniuchi; Hiroaki Ueno; Shizuya Yamashita; Hisako Yoshida; Hiroyuki Tsutsui; Tetsuo Shoji
• Keywords: Male; Cross-Sectional Studies; Cholesterol; Cardiovascular Diseases; Humans; Phytosterols; Original Article; Female; Coronary Artery Disease; Middle Aged; Biomarkers; 3. Good health

Serum levels of cholesterol absorption and synthesis markers have been associated with cardiovascular risk in the United States European countries. In this study, we examined relevance these biomarkers presence disease (CVD) Japanese individuals.The CACHE consortium, comprising 13 research groups Japan possessing data on campesterol, an marker, lathosterol, a marker measured by gas chromatography, compiled clinical using REDCap system.Among 2,944 individuals population, those missing campesterol or lathosterol were excluded. This cross-sectional study was able to analyze from 2,895 individuals, including 339 coronary artery (CAD) patients, 108 cerebrovascular (CeVD) 88 peripheral (PAD) patients. The median age 57 years, 43% female, low-density lipoprotein triglyceride 118 mg/dL 98 mg/dL, respectively. We assessed associations ratio (Campe/Latho ratio) odds CVD multivariable-adjusted nonlinear regression models. prevalence CVD, especially CAD, showed positive, inverse, positive Campe/Latho ratio, These remained significant even after excluding statins and/or ezetimibe. PAD determined weaker than CAD. Contrarily, no association noted between metabolism CeVD.This that both high low biomarker