Intestinal dysbiosis and increased intestinal permeability as a potential risk factor for the development and progression of rheumatoid arthritis

• DOI: 10.5603/rf.2022.0024
• Publication Date: 2023-12-30T16:02:57Z
• Authors: Karolina Zofia Wąż; Eugeniusz Józef K...; Magdalena Kopeć-M...; Robert Pieczyrak; Przemysław Kotyla
• Keywords: Intestinal Permeability; Dysbiosis; Genetic predisposition; Pathogenesis

Rheumatoid arthritis (RA) is one of the most common autoimmune diseases. Factors affecting development disease result from a coincidence environmental factors, including so-called trigger factors and genetic predisposition which lead to impaired immune tolerance phenomena. The detailed etiopathogenesis unclear. Evidence indicates potential role gut microbiome, increased intestinal permeability disturbed response faciliate diseases RA. paper reviewing scientific data on microbiota in progression Attention also focused disrupting physiological microbial colonization other related modern lifestyle industrialized countries microbiota. All reported suggested pathogenesis RA further work necessary determine whether modulation can serve as clinical tool regulate influence course