Neurometabolic activity in the thalamic and frontal cortex and cognitive functions in adolescents with generalized epileptic syndromes

• DOI: 10.5604/01.3001.0054.4903
• Publication Date: 2024-05-13T09:16:30Z
• Authors: Izabela Kaczmarek; Joanna Michalska; Wojciech Kociemba; Sylwia Antczak; Barbara Steinborn
• Keywords: Frontal cortex; Generalized epilepsy

The study aimed to analyse the mutual correlations between metabolic activity of brain evaluated by magnetic resonance spectroscopy method (MRS) and intelligence cognitive functions in adolescents with idiopathic generalised epilepsies (IGE). focus was placed on thalamus frontal cortex.Twenty newly diagnosed patients juvenile absence epilepsy (JAE) myoclonic (JME) were included study. Adolescents underwent primary structural neuroimaging (1.5T) advanced evaluation cortex MRS. Concentrations N-acetyl aspartate (NAA), creatine plus phosphocreatine (Cr) choline (Cho) measured expressed as ratios NAA/Cr, NAA/Ch NAA/Cr+Ch. Patients also completed a panel IQ tests (e.g., FePsy Battery – classification test, verbal fluency RAVLT memory test). correlation level metabolites results intellectual examined.Strong found some IGEs group. Overall whose NAA/Ch, NAA/Cr+Ch lower, obtained worse neuropsychological tests.The metabolite impacts group IGE.