Clerodane Diterpenes Isolated from Polyalthia longifolia Induce Apoptosis in Human Leukemia HL-60 Cells

• DOI: 10.5650/jos.62.843
• Publication Date: 2013-10-01T23:10:19Z
• Authors: Dina Permata Sari; Masayuki Ninomiya; Mai Efdi; Adlis Santoni; Sanusi Ibrahim; Kaori Tanaka; Mamoru Koketsu
• Keywords: Fragmentation

Polyalthia is a versatile genus of shrubs and trees found in tropic sub-tropic regions. In this study, three clerodane diterpenes, kolavenic acid (1), polyalthialdoic (2), 16α-hydroxy-cleroda-3,13(14)Z-dien-15,16-olide (3) isolated from longifolia leaves were evaluated for their apoptotic potential against human leukemia HL-60 cells. Compounds 2 3 inhibited cell proliferation with IC50 values 21.8 13.7 μM, respectively. Morphological changes DNA fragmentation analysis indicated that these diterpenes induce death the Our results revealed importance P. as chemopreventive medicinal plant.