Sleep and Antibody Response to Hepatitis B Vaccination

• DOI: 10.5665/sleep.1990
• Publication Date: 2012-07-31T14:30:26Z
• Authors: Aric A. Prather; Martica Hall; Jacqueline M. Fury; Diana C. Ross; Matthew F. Muldoon; Sheldon Cohen; Anna L. Marsland
• Keywords: Sleep; Antibody titer; Hepatitis B vaccine; Hepatitis A vaccine

Experimental evidence links poor sleep with susceptibility to infectious illness; however, it remains be determined if naturally occurring is associated immune responses known play a role in protection against infection. The aim of this study was determine whether duration, efficiency, and quality, assessed the natural environment, predict magnitude antibody novel antigen among community volunteers midlife. Observational. Healthy midlife adults (n = 125; 70 female; age 40-60 yr) received standard 3-dose hepatitis B vaccination series. Actigraphy electronic diaries were used assess subjective quality. Viral-specific titers obtained prior 2nd 3rd primary secondary responses. Clinical status (anti-hepatitis surface immunoglobulin G ≥ 10 mIU/ml) 6 mo after final immunization. Regression analyses revealed that shorter actigraphy-based duration lower response independent age, sex, body mass index, initial Shorter measured by actigraphy diary, also predicted decreased likelihood being clinically protected from at conclusion Neither efficiency nor quality significant predictors response. Short environment may negatively affect vivo antigens, providing possible explanation for observed associations increased disease.