Hip fracture in elderly men: the importance of subclinical vitamin D deficiency and hypogonadism

• DOI: 10.5694/j.1326-5377.1998.tb116014.x
• Publication Date: 2019-02-27T21:31:29Z
• Authors: Terrence Diamond; Peter Smerdely; Nie Kormas; Ronald Sekel; Tung Vu; Peter Day
• Keywords: Hip Fracture; Subclinical infection; Outpatient clinic

Objective: To determine the major risk factors for hip fracture in elderly men. Design: Prospective recruitment, followed by analysis of clinical and biochemical variables. Patients setting: Men aged 60 years older who presented to St George Hospital (a 650-bed tertiary-care centre) 1995, comprising all 41 men with fractures, as well hospital inpatient outpatient control subjects without fractures. Main outcome measures: Osteoporotic (including age, body weight, comorbid illnesses, alcohol intake, cigarettes smoked, corticosteroid use) serum concentrations creatinine, urea, calcium, albumin, alkaline phosphatase, parathyroid hormone, 25-hydroxyvitamin D free testosterone. Results: There were no significant differences between two groups on any osteoporotic factors. had significantly lower mean concentration (45.6 nmol/L; 95% confidence interval [Cl], 36.9–52.3 nmol/L) than both (61.1 Cl, 50.0-72.2 (65.9nmol/L; 95%CI, 59.0-72.8 controls (P=0.007). Subclinical vitamin deficiency (defined <50 nmol/L 25- hydroxyvitamin D) was 63% group, compared 25% combined (odds ratio, 3.9; 1.74-8.78; P⩵0.0007). Inpatients fractures calcium testosterone outpatients (P < 0.05). In a multiple regression analysis, subclinical strongest predictor (B [regression coefficient], 0.34±0.19; P⩵0.013). Conclusions: Australian may contribute development through effects secondary hyperparathyroidism, resulting increased bone loss.