An exaggerated capillary endothelial edema may be the cause of sudden deaths in sickle cell diseases

• DOI: 10.5742/mewfm.2023.95256120
• Publication Date: 2023-07-10T02:15:05Z
• Authors: Mehmet Rami Helvaci; Ummuhan Kodal Tun...; Kubra Seckin; Kubra Piral; Sare Seyhan; Ayse Deniz Karabacak; Mehpare Camlibel; Abdulrazak Abyad; Lesley Pocock
• Keywords: Endothelial Dysfunction; Hypoxia

Background: Sickle cell diseases (SCDs) are inborn and severe inflammatory processes on vascular endothelium, particularly at the capillaries which actual distributors of sickled or just hardened red blood cells (RBCs) into tissues. Methods: All patients SCDs were included. Results: We studied 222 males 212 females with similar ages (30.8 vs 30.3 years, p>0.05, respectively). Disseminated teeth losses (5.4% 1.4%, p<0.001), ileus (7.2% cirrhosis (8.1% 1.8%, leg ulcers (19.8% 7.0%, digital clubbing (14.8% 6.6%, coronary heart disease (18.0% 13.2%, p<0.05), chronic renal (9.9% 6.1%, obstructive pulmonary (25.2% stroke (12.1% 7.5%, p<0.05) higher in but not acute chest syndrome (2.7% 3.7%), hypertension (12.6% 11.7), deep venous thrombosis and/or varices telangiectasias (9.0% 6.6%), mean age mortality (30.2 33.3 years) (p>0.05 for all). Conclusion: The RBCs-induced capillary endothelial damage, inflammation, edema, fibrosis initiated birth, terminate disseminated tissue hypoxia, multiorgan failures, sudden deaths even childhood. Although RBCs suspensions corticosteroids aspirin plus hydroxyurea phases decrease severity destructive process, survivals still shortened both genders, dramatically. Infections, medical surgical emergencies, emotional stresses-induced increased basal metabolic rate aggravates sickling may failures-induced SCDs. Key words: diseases, cells, exaggerated