Does Postoperative Serum Interleukin-6 Influence Early Recurrence after Curative Pulmonary Resection of Lung Cancer?

• DOI: 10.5761/atcs.oa.10.01627
• Publication Date: 2011-07-13T12:13:21Z
• Authors: Hidefumi Kita; Yuji Shiraishi; Kenichi Watanabe; Kazuharu Suda; Kouki Ohtsuka; Yoshihiko Koshiishi; Tomoyuki Goya
• Keywords: Male; Analysis of Variance; Chi-Square Distribution; Lung Neoplasms; Interleukin-6; Kaplan-Meier Estimate; Disease-Free Survival; 3. Good health; 03 medical and health sciences; 0302 clinical medicine; Japan; Carcinoma, Non-Small-Cell Lung; Humans; Female; Postoperative Period; Prospective Studies; Inflammation Mediators; Neoplasm Recurrence, Local; Pneumonectomy; Biomarkers; Aged; Neoplasm Staging; Proportional Hazards Models

Purpose: We examined the influence of inflammatory cytokine levels on postoperative early recurrence in patients who underwent curative lung cancer surgery. Methods: In 107 pulmonary resections for non-small cell (NSCLC) from November 2007 to June 2008, we measured serum interleukin-6 (IL-6) preoperatively, and day (POD) 0, 1, 2. Between July 2009 August 2009, 1 year after date enrollment last patient, investigated survival status each patient identified a group with recurrence.Results: Among patients, 29 developed mean follow-up 18.1 months (range 14 21). P-stage was significantly more advanced than non-recurrence (p = 0.005). Serum IL-6 POD were higher 0.007). Cox's proportional hazards regression, significant independent predicting factors 0.006, p 0.003).Conclusions: The risk recurrence, even when resection can be accomplished patients.