The Effect of Circadian Melatonin Levels on Inflammation and Neurocognitive Functions Following Coronary Bypass Surgery

• DOI: 10.5761/atcs.oa.14-00357
• Publication Date: 2015-05-25T08:06:05Z
• Authors: Sırma Geyik; Remzi Yiğiter; Aylin Akçalı; Hayati Deniz; Abidin Murat Geyik; Mehmet Ali Elçi; Erhan Hafız
• Keywords: Neurocognitive; Elective surgery; Bypass surgery

In this study, the relationship between plasma levels of melatonin and intercellular adhesion molecule-1 (ICAM-1), which plays role in several interactions including inflammatory immune responses, early neurocognitive functions associated with ischaemia-reperfusion injury during open heart surgery is examined.Forty patients who were to undergo elective coronary artery bypass grafting (CABG) divided into two groups, those underwent their operations at 8 AM (group I; n = 20) 1 PM II; 20). Blood samples collected prior (S1), when aortic cross clamp was removed (S2) 4 (S3) 24 h after (S4). Neuropsychiatric assessment conducted one day before seven days surgery.Melatonin measured also significantly higher Group 1. ICAM-1 lower S2 S3. Significant deterioration observed postoperative function compared preoperative 2 more than 1.We hypothesise that greater preservation morning elevated levels, reduce damage from injury.