Effect of Swimming Exercise to Cardiac PGC-1 α and HIF-1 α Gene Expression in Mice

• DOI: 10.5812/asjsm.65079
• Publication Date: 2018-09-29T08:46:52Z
• Authors: Nova Sylviana; Niswan Helja; Hadaral Hudanul Q...; Hanna Goenawan; Ronny Lesmana; Mas Rizky A A Sya...; Hasrayati Agustina; Badai Batara Tiks...; Imam Megantara; Vita Murniati Tar...; Setiawan Setiawan; Bethy Hernowo; Unang Supratman; Ambrosius Purba
• Keywords: Hypoxia; Cardiac muscle

Background: Hypoxia caused by exercise condition may alter PGC-1α and HIF-1α expression in cardiac cells. Both factors are transcriptional which play a role conserving energy during metabolic process. However, there is less information about the effects of long term moderate intensity such as swimming on Objectives: Aim this study to observe effect force gene muscle mice. Methods: Male BALBc mice were divided into two groups (n = 10): control (C) (ST). ST group was subjected for 4 weeks, 30 minutes/day 5 days. Hearts animal models preserved morphology using HE staining, mRNA study. Results: We observed that significantly increased 1.5 fold compared with (0.64 vs 0.44; CI 95%, -0.378 - 0.019; P 0.035), but decreased 0.4 times lower than (0.35 0.52; 0.27 0.31; 0,025). Conclusions: Taken together, response chronic hypoxia condition.