Plasma Osteopontin Level in Chronic Liver Disease and Hepatocellular Carcinoma

• DOI: 10.5812/hepatmon.30753
• Publication Date: 2015-09-06T07:17:46Z
• Authors: Shawky Abdelhamid...; Nagwa Abdel Ghaff...; Mary Wadie Fawzy; Doaa Ali Moustafa
• Keywords: Osteopontin; Liver function; Chronic liver disease; Liver disease

Osteopontin (OPN) is a secreted glycoprotein and frequently associated with various tumors.We sought to investigate the clinical usefulness of level plasma OPN, compared α-fetoprotein (AFP), as biomarker for hepatocellular carcinoma (HCC) evaluate its diagnostic value in nonalcoholic fatty liver disease (NAFLD) relationship laboratory features HCC NAFLD.The study was performed on 120 subjects classified into 5 groups: Group I included 25 chronic non-cirrhotic hepatitis C virus (HCV)-infected patients; II encompassed patients HCV infection cirrhosis; III comprised cirrhosis HCC; IV NAFLD; V consisted 20 healthy age- sex-matched controls. All participants were subjected history taking abdominal ultrasonographic examinations well following investigations: function tests, complete blood count, sugar, B surface antigen, antibodies, HCV-RNA by qualitative polymerase chain reaction (for Groups I, II, III) serum AFP OPN levels.There statistically significant differences levels between group (401 ± 72 ng/mL) other groups, cirrhotic (258.3 35 (HCV group, 168.7 41 ng/mL; 106.7 ng/mL), (I IV) controls (35.1 6 ng/mL). In comparable that at cutoff 280 ng/mL, achieving sensitivity, specificity, overall accuracy 100%, 98%, 96%, respectively. Regarding validity predictor change, our results revealed 50% 70% 45% positive predictive value, 75% negative 134 ng/mL.Plasma marker related severity involvement patients. Plasma potential NAFLD.