G1896A Precore Mutation and Association With HBeAg Status, Genotype and Clinical Status in Patients With Chronic Hepatitis B

• DOI: 10.5812/hepatmon.31490
• Publication Date: 2015-10-31T06:59:30Z
• Authors: Jeyanthi Suppiah; Rozainanee Mohd Zain; Norazlah Bahari; Salbiah Haji Nawi; Zainah Saat
• Keywords: Asymptomatic carrier; Hepatitis B; HBeAg

Precore stop codon (G1896A) mutation is one of the commonest mutations found in patients with chronic hepatitis B. However, over years, this was not reported much Malaysia.We therefore investigated presence G1896A Malaysian population and its association HBeAg status, clinical stage, B virus (HBV) genotype e-seroconversion rate.Serum samples from 93 confirmed as carriers were collected for molecular assay. The whole genome HBV amplified by polymerase chain reaction directly sequenced. precore basal core promoter regions analyzed mutations.The most commonly observed region C1858T 64.5% prevalence. interest identified 25.8% isolates. detected A1762T-G1764A (26.9%), C1653T (8.6%), A1752G (10.8%) C1766T (2.2%). No significant between HBeAg-negativity. Nonetheless, highly prevalent among Clinical revealed that subjects mainly asymptomatic (58.3%) liver cirrhosis (41.7%). One subject diagnosed fulminant (4.2%) 8.3% had hepatocellular carcinoma (HCC).Our data suggested an intermediate prevalence carriers. has a cirrhosis.