Oxidative Stress as the Underlying Biomechanism of Detrimental Outcomes of Ionizing and Non-Ionizing Radiation on Human Health: Antioxidant Protective Strategies

• DOI: 10.5812/zjrms.85655
• Publication Date: 2019-10-26T10:03:11Z
• Authors: Abolfazl Akbari; Gholamali Jelodar; Saeed Nazifi; Tayyaba Afsar; Khadijeh Nasiri
• Keywords: Hormesis; Non-ionizing radiation; Cell damage

Context: The deleterious effects of ionizing and non-ionizing radiations occur through non-thermal thermal effects. Thermal particularly at long wavelength with heating properties increase temperature the tissue. are due to changes in structure functions cell membrane, genetic effects, extracellular /intracellular signaling pathways, oxidative stress. Objectives: Oxidative stress referring overproduction reactive oxygen species (ROS) /or deficiency antioxidant defense mechanisms acts like a double-edged sword. Therefore, modification endogenous antioxidants activity production ROS have significant role controlling such conditions. Methods: current review study focused on after exposure defense. Results: results many studies suggested that both (e.g., radiofrequency electromagnetic fields emitted from mobile phones other wireless technologies) may activate oxidizing events, which transform atomic change macromolecules structures as proteins, lipids, DNA. Conclusions: It can be concluded physiological responses cells injurious stimuli by cause impairment via damage, also phenomenon known adaptive response. In fact, rate production, redox state cell, previous exposures harmful agents along factors contribute prevalence each responses.