Association of Lipids, Lipoproteins, and Apolipoproteins with Stroke Subtypes in an International Case Control Study (INTERSTROKE)

• DOI: 10.5853/jos.2021.02152
• Publication Date: 2022-06-02T05:06:46Z
• Authors: Martin J. O’Donnell; Matthew McQueen; Allan Sniderman; Guillaume Pare; Xingyu Wang; Graeme J. Hankey; Sumathy Rangarajan; Siu Lim Chin; Purnima Rao-Melacini; John Ferguson; Denis Xavier; Liu Lisheng; Hongye Zhang; Prem Pais; Patricio Lopez-Ja...; Albertino Damasceno; Peter Langhorne; Annika Rosengren; Antonio L. Dans; Ahmed Elsayed; Alvaro Avezum; Charles Mondo; Conor Judge; Hans-Christoph Di...; Danuta Ryglewicz; Anna Czlonkowska; Nana Pogosova; Christian Weimar; Romana Iqbal; Rafael Diaz; Khalid Yusoff; Afzalhussein Yusu...; Aytekin Oguz; Ernesto Penaherrera; Fernando Lanas; Okechukwu S. Ogah; Adesola Ogunniyi; Helle K. Iversen; German Malaga; Zvonko Rumboldt; Shahram Oveisgharan; Fawaz Al Hussain; Yongchai Nilanont; Salim Yusuf
• Keywords: Stroke; Dyslipidemia

The association of dyslipidemia with stroke has been inconsistent, which may be due to differing associations within etiological subtypes. We sought determine the lipoproteins and apolipoproteins subtypes.Standardized incident case-control STROKE study in 32 countries. Cases were patients acute hospitalized first stroke, matched by age, sex site controls. Concentrations total cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density (LDL-C), apolipoprotein A1 (apoA1), apoB measured. Non-HDL-C was calculated. estimated multivariable odds ratio (OR) population attributable risk percentage (PAR%). Outcome measures all ischemic (and subtypes), intracerebral hemorrhage (ICH).Our analysis included 11,898 pairs; 77.3% 22.7% ICH. Increasing (OR, 1.10; 95% confidence interval [CI], 1.06 1.14 per standard deviation [SD]) LDL-C 1.06; CI, 1.02 1.10 SD) associated an increase but a reduced Increased significantly large vessel (PAR 13.4%; 5.6 28.4) undetermined cause. Higher HDL-C 0.75; 0.72 0.78 apoA1 0.63; 0.61 0.66 subtypes). While increasing increased ICH 1.20; 1.27 SD), 0.80; 0.75 0.85 SD). ApoB/A1 1.38; 1.32 1.44 had stronger magnitude than LDL-C/HDL-C 1.26; 1.21 1.31 (P<0.0001).The pattern varies subtype. directions for LDL, HDL, opposing ICH, reduction both apoB/A1 best lipid predictor risk.