Prostatic Ductal Adenocarcinoma Controlled for Tumor Grade, Stage, and Margin Status Does Not Independently Influence the Likelihood of Biochemical Recurrence in Localized Prostate Cancer After Radical Prostatectomy

• DOI: 10.5858/arpa.2021-0048-oa
• Publication Date: 2021-11-05T18:36:24Z
• Authors: Oleksandr N. Kryv...; Oleksii A. Iakymenko; Luiz P. De Lima G...; Amit S. Bhattu; Ali Merhe; Ali Mouzannar; Laurence M. Briski; Irfan Oymagil; Isabella Lugo; Ivan Nemov; Chad R. Ritch; Bruce R. Kava; Sanoj Punnen; Merce Jorda; Dipen J. Parekh; Mark L. Gonzalgo
• Keywords: Biochemical recurrence; Surgical margin

Prostatic ductal adenocarcinoma (PDA) has historically been considered to be an aggressive subtype of prostate cancer.To investigate if PDA is independently associated with worse biochemical recurrence (BCR)-free survival after radical prostatectomy.A review 1584 prostatectomies was performed grade, stage, and assess margin status in each tumor nodule. Radical localized (ie, those lacking metastasis) the nodule highest grade stage worst were matched prostatic acinar according status. The effect on BCR assessed by multivariable Cox regression Kaplan-Meier analyses.Prostatic present 171 cases. We excluded 24 cases because lymph node metastasis (n = 13), not highest-grade 9), positive surgical a lower-grade 2). remaining 147 included 26 Grade Group (GG) 2, 44 GG3, 6 GG4, 71 GG5 cancers. Seventy-six had extraprostatic extension, 33 seminal vesicle invasion, 65 margins. Follow-up available for 113 109 Prostate-specific antigen density (odds ratio, 3.7; P .001), cancer 3.3-4.3; .02), 1.7; volume 1.3; .02) analysis. adenocarcinoma, its percentage, intraductal carcinoma, cribriform Gleason pattern 4 significant independent predictors BCR.Advanced locoregional higher rather than mere presence are more predictive BCR-free outcomes following prostatectomy men component PDA.